Thimmalapura Marulappa Vishwanatha

Dynamic professional with extensive hands-on experience in simple and multistep organic synthesis and peptide chemistry, adept at navigating complex challenges. Strong problem-solving abilities combined with a proactive approach ensure effective solutions are consistently delivered. Recognized for adaptability, creativity, and a results-oriented mindset that drives success across various projects. Committed to making meaningful contributions that align with and advance organizational goals.

• Best Prize for developing site-selective ligation reaction, Thematic school on Chemical protein synthesis and Bioconjugations. PEPPER School, May 2018, Carry-Le-Route, France.
• Travel grant 26th American Peptide Symposium, June 22nd – 27th 2019, Monterey, California, USA.
• LE STUDIUM/Marie Sklodowska-Curie Research Fellowship (February 2019 – April 2020), CNRS, CBM, Orléans, France.
• Travel grant An international symposium in Chemical biology, January 10th – 12th, 2018, Geneva Switzerland.
• Senior Research Fellowship (April 2012 – February 2014), Bangalore University, India.

Articles Published – 36

Patents – 03 (1 is under filing process)

First Author – 13

Second Author – 11

Others – 14

Submitted – 02 (As a first author)

In preparation – 01 (As a first author)

Google Scholar – https://scholar.google.com/citations?hl=en&user=JipfwGoAAAAJ

• Vishwanatha, T. M.; Imma, C. Dömling, A. Direct biology approach towards the Y220C mutant PROTACs library and studies on their cell degradation studies. Submitted (J. Am. Chem. Soc.)
• Vishwanatha, T. M.; van Doodeweerd, B. R.; Pol, V.; van der Heden van Noort, G. J.; Mulder, M. P. C.; Geurink, P. P. Automated combinatorial synthesis of an oxadiazole library using a multi-component reaction to target deubiquitinating proteases. under major revision (Angew. Chem. Int. Edn.)
• Vishwanatha, T. M.; Vincent, R.; Didier, L.; Vincent, A.; Massimiliano, B. Diversity-oriented macrocyclic peptide library generation on solid support: a rapid approach for identifying potent and selective peptide in GPCR targets and their invivo studies. Under revision (Chem. Sci.)
• David, A. P.; Vishwanatha, T. M.; Horn-Ghetko, D.; Botsch, J. J.; Hehl, L. A.; Kostrohn, S.; Misra, M.; Đikić, I.; Geurink, P. P.; van Dam, H.; Schulman, B. A.; Mulder, M. P. C. et al. A pro-fluorogenic Ubiquitin-based probe to monitor cysteine-based catalytic E3 Ligase activity. Angew Chem. Int. Edn., 2023.
• Vishwanatha, T. M.; Giepmanis, B.; Goda, S. K. Dömling, A. Tubulysin Synthesis Featuring Stereoselective Catalysis and Highly Convergent Multicomponent Assembly. Org. Lett. 2020, 22, 5396 – 5400.
• Montoir, D.; Amoura, M. ; Abasa, Z. E. A. ; Vishwanatha. T. M. ; Yen-Pon, E. ; Robert, V. ; Beltramo, M. ; Piller. V. ; Alami, Y. ; Aucagne, V. ; Messaoudi, S. Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation. Chem. Sci. 2018, 9, 8753 – 8759.
• Vishwanatha, T. M.; Bergamaschi, E.; Dömling, A. Sulfur-Switch Ugi-Reaction For Macrocyclic Disulfide-Bridged Peptidomimetic Synthesis. Org. Lett. 2017, 19, 3195 – 3198. (DOI: https://doi.org/10.1021/acs.orglett.7b01324)
• Vishwanatha, T. M.; Kurpiewska, K.; Kalinowska-TlusciK, J.; Dömling, A. Cysteine isocyanide: Concise multicomponent synthesis of peptidomimetic 1,3-azoles. J. Org. Chem. 2017, 82, 9585 – 9594. (DOI: https://doi.org/10.1021/acs.joc.7b01615)
• Vishwanatha, T. M.; Narendra, N.; Basab Chattopadhyay, Monika Mukherjee, Sureshbabu, V. V. Synthesis of selenoxo peptides and oligoselenoxo peptides employing LiAlHSeH. J. Org. Chem. 2012, 77, 2689 – 2702. (DOI: https://doi.org/10.1021/jo2024703)

• Thesis management and co-supervision of master and bachelor students
• 01 Imma Capriello, Ph.D., Co-supervision, at Palacky University, 02/2024 – on going Olomouc, Czech Republic
• 02 Mayur Mukim, Ph.D., Co-supervision, at Palacky University, 05/2024 – on going Olomouc, Czech Republic
• 03 Mike, Master’s project, LUMC, The Netherlands 03/2021 – 02/2022
• 04 Renan Vinicius de Araújo, Bachelor’s project, University of Groningen, The Netherlands. 03/2016 – 12/2016
• 05 Kees Wildeveld, Master’s project, University of Groningen, The Netherlands. 03/2016 – 02/2017
• 06 Enrico Bergamaschi, Bachelor’s project, University of Groningen, The Netherlands. 01/2016 – 06/2016
• 07 Pallavi T. R. Master’s project at Bangalore University, India 02/2011 – 06/2011

• Challenges and prospects in chemoselective ligations: from protein synthesis to site-specific conjugation” LE STUDIUM International Conference, January 27th – 29th, 2020, Orléans, France.
• 1st Innovative conference chemistry and chemical biology, 1st and 2nd October, 2025, Olomouc, Czech Republic.

• Prof. dr. Alexander, Dömling, Palacky University, Olomouc, Czech Republic. Email: alexander.domling@upol.cz,
• Dr. Monique, Mulder, Leiden University Medical Center, Leiden, The Netherlands. Email: m.p.c.mulder@lumc.nl,
• Dr. Vincent, Aucagne, CNRS Centre de Biophysique Moléculaire, Orléans, France, UPR 4301. Email: aucagne@cnrs-orleans.fr,